Statistically derived asymmetric membrane potentials from α-helical and β-barrel membrane proteins
نویسندگان
چکیده
منابع مشابه
A predictor of membrane class: Discriminating α-helical and β-barrel membrane proteins from non-membranous proteins
Accurate protein structure prediction remains an active objective of research in bioinformatics. Membrane proteins comprise approximately 20% of most genomes. They are, however, poorly tractable targets of experimental structure determination. Their analysis using bioinformatics thus makes an important contribution to their on-going study. Using a method based on Bayesian Networks, which provid...
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β-barrel membrane proteins are composed of multiple antiparallel β-strands and form pores in the outer membranes of endosymbiotic organelles like mitochondria and the evolutionary related Gramnegative bacteria. These β-barrel channels are crucial for signal transduction, metabolite transport, and protein translocation. How are β-barrel membrane proteins assembled into the outer membrane? After ...
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Integral membrane proteins fall into two major structural classes; they consist of individual or bundled TM -helices, or they form monomeric, dimeric, or trimeric TM -barrels. These folds are dictated by the necessity to form oriented hydrogenbonded secondary structures in the highly ordered apolar environment of the lipid bilayer. No other structural motif has yet been confirmed for membrane p...
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Grease to grease - this is how one might begin to describe the tendency of hydrophobic stretches in protein amino acid sequences to form transmembrane domains. While this simple rule contains a lot of truth, the mechanisms of membrane protein folding, the insertion of hydrophobic protein domains into the lipid bilayer, and the apparent existence of highly polar residues in some proteins in the ...
متن کاملFunctional fragments of disorder in outer membrane β barrel proteins
The traditional view of "sequence-structure-function" has been amended by the discovery of intrinsically disordered proteins. Almost 50% of PDB structures are now known to have one or more regions of disorder, which are involved in diverse functions. These regions typically possess low aromatic content and sequence complexity as well as high net charge and flexibility. In this study, we examine...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-22476-6